It happened just before 2 pm Sunday at the intersection of Iona and 14th Avenues, south of Armona.
The California Highway Patrol says a 17-year-old girl was driving a Hyundai Elantra east on Iona when she went through a stop sign.
A Chevy Suburban traveling north on 14th Avenue then collided with the side of the Hyundai.
One passenger in the Hyundai died as a result of the crash.
Another passenger was hospitalized with major injuries.
The cause of the crash remains under investigation, though officers do not believe alcohol or drugs were factors.