Officers say the driver of a Ford Expedition was westbound on Highway 198 near the Lemoore Avenue exit in Lemoore when his SUV rolled off the roadway, crashing into an orchard.
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The man was thrown from the vehicle. Investigators say he wasn't wearing a seatbelt.
He was taken to a local hospital. His condition has not been released.
CHP officers say they believe the misty conditions caused by the fog made the roadway wet and slick.
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The cause of the crash is still under investigation.