Officers were called to Houston and 16th Avenues just before 1 a.m.
Officials say for some reason, a woman lost control of her vehicle, striking a pole along with a fence, some large stones and a tree.
The pole was severely damaged from the collision, leaving more than 500 PG&E customers without power, the CHP said.
Wires also tumbled down into the roadway, and crews had to shut down a large portion of Houston Avenue to clear the wreckage.
The driver was rushed to a nearby hospital.
California Highway Patrol officers believe the woman was under the influence of alcohol and cannabis while driving.
PG&E reported that 76 customers are still without power. The outage is expected to be restored around 7 a.m. For more information on the outage, click here.