It happened after 1:30 am at the Les Schwab tire shop Kings Canyon Road and Argyle.
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Firefighters received an alarm from the building's sprinkler system.
When crews arrived, they found one of the rollup doors partially open and a burning vehicle inside.
Firefighters acted quickly to contain the fire.
"They arrived on scene and finding the doors open like that the fire would be suspicious, so we're going do a thorough investigation. When I first arrived, the captain didn't notice anyone immediately in the vicinity of the fire," said Fire Battalion Chief Sean Johnson.
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Investigators say one car was engulfed in flames. There were burning materials underneath several other vehicles inside the building.
No one was hurt.
Officials have not released any information about a possible suspect.