Officers were called to a house on Park Warren Drive near San Luis Street around 9:55 pm. There they found a 34-year-old man who had been shot twice in the upper body.
The man was taken to a hospital in Modesto, where he later died. His name has not been released.
Investigators say the man had been in his garage when someone drove up, got out of a vehicle and opened fire.
Police believe the shooting is gang-related. Detectives do not have a description of the suspect or their vehicle.
Anyone with information is asked to call the Los Banos Police Department at 209-827-7070.