The California Highway Patrol says it happened at 6:45 am on Avenue 9 near Children's Boulevard.
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Officers say a Honda Civic going east went into the westbound lane and crashed head-on with a Toyota Corolla.
The driver of the Civic and a passenger in the Corolla died from their injuries.
Two other people in the Corolla were taken to Community Regional Medical Center for treatment.
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Officers have not identified the victims but said they were all men.
The three inside the Toyota are family members.
Officers believe the Honda may have been speeding through a curve in the road, causing that driver to cross over into the oncoming lane.