They happened at about 1:45 Tuesday morning on Highway 99 and Madera Avenue.
Officers were responding to the scene of one collision when the second crash occurred.
Two vehicles and a big rig were involved.
Officers says there were major injuries.
Lanes were blocked off for about two hours while officers cleared the scene.
The area is now back open to traffic.
We're still waiting to learn more about the conditions of those injured in these crashes.