The crash happened on Highway 99 and V Street in Merced on Wednesday night.
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California Highway Patrol officials say the big rig driver was northbound on Highway 99 at a slow rate of speed due to road construction.
That's when the driver of a Mazda crashed into the rear trailer. Paramedics pronounced the driver dead at the scene.
Officials say there were several signs in the area warning of the road construction.
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It is unknown at this time if drugs or alcohol played a role in this crash.