It happened on Tuesday at 10 p.m. on Interstate 5 near Sullivan Road.
The fiery aftermath of the crash was captured by ABC30 insider Larry Chatfield.
The Highway Patrol says a big rig crashed into a Chevy suburban with a U-Haul trailer.
The semi caught on fire and the crash caused a traffic delay.
The number one and two lanes along I-5 were closed off for several hours.
It's not yet known which driver was killed in the crash.