The California Highway Patrol stopped a tractor-trailer heading north on Interstate 5 near the Stockdale Highway in Kern County around 12:15 Tuesday night.
The officer noted signs of criminal activity and asked to search the vehicle.
Officials say a K9 unit responded and found about 95 pounds of meth inside suitcases the semi was carrying.
The driver was taken into custody and booked in Kern County Jail for several drug charges.