Officers were called to Shields and Fresno around 9 Monday morning for reports of a car chasing a motorcycle in a possible road rage incident.
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Moments later, the vehicles crashed at Blackstone and Saginaw.
44-year-old Kair Saephan was taken to the hospital, where he died.
Detectives now believe the other driver intentionally drove into the motorcycle.
The suspect has been detained for questioning.
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Police say witnesses told them someone involved in the crash had a gun but officers didn't find any weapons at the scene.
Officers are now talking to nearby businesses to get surveillance video of the crash.