It happened just after 8 am.
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Officers say the two victims, a man and woman, were on a motorcycle traveling south on Highway 33 near Marshall Road when they hit the back of a GMC truck.
The man and woman were thrown from the bike.
Investigators say minutes later, a big rig hit the motorcycle in the roadway, then drove away. CHP officers said it's possible the semi also hit both victims.
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Officials say the big rig was hauling a white tractor-trailer and may have some damage to the front of the vehicle.
The CHP said foggy conditions likely caused the crash.