Police got a report of a man lying in the road on Tuolumne Street near Highway 99, just before 1 a.m.
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They found a man in his twenties who was conscious and breathing but needed medical help.
Witnesses told police they saw a black SUV driving down the freeway frontage road when it hit the wrong-way motorcyclist.
Investigators believe the SUV got on the freeway and drove away, but they didn't have a description of the driver.
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They're looking for surveillance video to help with that.