Authorities have identified the man as 34-year-old Dennis Brown of Visalia.
The Fresno Police Department says it happened around 2:30 pm on Herndon Ave. near Blythe Ave.
Witnesses told police that the man was at a red light and when it turned green, he went at a high speed.
Police say Brown lost control of the motorcycle and crashed into a tree. He was taken to Community Regional Medical Center, where he died.