24-year-old Jaspreet Singh Chahal, of Fresno, was charged with homicide by vehicle, reckless driving and related offenses.
The crash happened November 14 on Interstate 78 in Berks County, Pennsylvania.
The victims, 42-year-old Joseph Kearney and 35-year-old Kathryn Schurtz of Jersey City were headed to Pittsburgh.
According to police, Chahal's truck hit the couple's SUV from behind. The impact pushed the SUV into several other tractor-trailers, and the vehicles caught fire.
A warrant has been issued for Chahal's arrest.