It happened just before 10 pm on southbound Highway 41 near Bullard Avenue.
Officers say an SUV collided with the motorcyclist near the on-ramp to the highway, causing the SUV to overturn.
The motorcycle rider, who police say is in his 60s, suffered major injuries/ He was taken to a nearby hospital.
The SUV driver tried to run away from the scene but was soon found by police. Officials say he's a man in his mid-20s. He was arrested for DUI and hit and run charges.
He suffered minor injuries.