According to the Santa Ana Police Department, the collision was reported shortly before 5:30 a.m. near the intersection of 17th and French streets.
The white Nissan Altima crossed three lanes on 17th before it hit a center divider, soared into the air and plowed into the two-story structure, the Orange County Fire Authority said.
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The incident caused a small fire that injured one person, who managed to get out of the sedan unassisted, the OCFA said.
Firefighters responded to the scene and extinguished the blaze, then extricated a second person who was trapped inside the sedan.
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It was unclear if drugs or alcohol played a role in the crash, police said.