Officers were called just after 3 am to Almond Street at Elgin Avenue.
Dos Palos Police Chief Richard McEachin said the driver of a farm labor bus was pulling out of his driveway when he felt he'd run over something.
He got out and found a person dead beneath the vehicle.
Police believe the person may have been sleeping under the bus before they were run over.
Dos Palos police have not identified the person.