It happened around 7 p.m. Friday on Kings Canyon Road near Burgan Avenue.
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Fresno police say the driver of the truck was traveling eastbound on Kings Canyon when they hit a person crossing the street.
First responders provided first aid to the person however, the person died at the scene due to their injuries.
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Officers say they are investigating what caused the crash.
The driver of the pick-up truck remained on scene and is cooperating with officers.