It happened on State Route 190 and Road 208, west of Porterville, just after 7:00 am.
The California Highway Patrol says a semi-truck carrying two empty trailers collided with a Chevy Suburban. Officers are working to determine what led up to the crash.
Officials say one person has died. It wasn't immediately clear if there were any other injuries.
Caltrans crews shut down part of Highway 190 for the investigation. The road has since reopened.