It happened before 6:30 am on northbound Highway 99 near Avenue 7.
The California Highway Patrol says the driver of a Toyota Camry was going the wrong way and crashed head-on with a semi-truck.
It caused the semi-truck to flip on its side and forced road closures.
A third vehicle was involved due to the initial impact of the crash.
Officers say no one suffered major injuries, but the driver of the semi-truck was taken to Community Regional Medical Center with a complaint of pain.
The driver of the Camry was arrested for DUI.