It happened before 7:30 am on Ventura and R.
Police say a 34-year-old woman was going west on Ventura at R Street when she drove into the intersection and crashed into the Factory 41 building.
The woman and her passenger were both rushed to Community Regional Medical Center, where the 34-year-old driver died.
The passenger is expected to be okay.
Police say alcohol may have been a factor in the crash.
The woman has not been identified.