It happened at 5:30 am Monday on Manning Avenue east of Chateau Fresno.
The California Highway Patrol says a Toyota Tundra was going west on Manning when it crashed head-on with a semi-truck.
The semi-truck driver went off the road and ended up in a vineyard.
Officers say the Tundra flipped and caught on fire.
The driver of the Tundra was thrown from the vehicle and declared dead at the scene.
The semi-truck driver suffered minor injuries and was taken to Community Regional Medical Center.
Officers are still investigating whether drugs or alcohol were factors in the crash.