The California Highway Patrol says the two cars collided just before 1 p.m. Thursday at the intersection of Auberry Road and Old Millerton Road.
Officers say the 18-year-old woman from Clovis was driving a Toyota sedan towards the intersection and failed to stop at the sign.
The woman's Toyota slammed into a Nissan sedan driven by an 88-year-old man from Prather, sending both cars into a nearby embankment.
His 100-year-old passenger died at the scene.
The driver and two other passengers in the Nissan were hospitalized with moderate to major injuries.
The 18-year-old was hospitalized with major injuries.
The crash remains under investigation and alcohol and drugs do not appear to be factors.