The shooting happened around 7 pm in the area of Raymond and Cleveland.
Madera police say two men had gotten into a fight leading up to he shooting.
Officials say one of the men was struck by gunfire and the second was injured during the fight.
They were both taken to the hospital, where their conditions are currently unknown.
Officers are asking drivers to avoid the area as the investigation continues.
Stay with Action News for the latest updates on this developing story.