The crash happened just before 5:00 p.m. when, according to CHP, a Lexus heading north on 99 crossed over the median and collided with a Dodge Ram traveling in the fast lane.
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CHP said the driver of the Lexus, a woman in her 40's, was killed along with her passenger, a teen, who was ejected from the car. The driver of the truck only suffered minor injuries.
The cause of the crash is still under investigation.
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Stay with Action News for more on this developing story.