The crash happened on Avenue 25 and Road 9 at about 2:30 p.m. Tuesday.
Photos from the CHP show a medical helicopter and one of the mangled vehicles.
Authorities say the driver of a Mazda ran a stop sign and rolled into the path of a large Ford truck.
The truck collided with the Mazda, which then crashed into a fence and power pole.
The man driving the Mazda and his two passengers were taken to the hospital with major injuries.
The driver of the truck had minor injuries.