Those employees have been working without a contract. Members of "Unite Here Local 2" authorized a strike last month amid contentious negotiations.
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The impacted hotels in San Francisco include: The Courtyard Marriott Downtown, The Marriott Marquis, Marriott Union Square, The Palace Hotel, The St. Regis, The W, And The Westin St. Francis.
Marriott says hotels will still remain open.
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It's the first strike for Marriott workers in San Francisco since 2004.
Workers went on strike in Boston earlier this week and are threatening to expand the strike to other cities.