Police say Oshae Carmeneal was found shot to death inside a home near Lamona and Delno around 1:30 am on Sunday.
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Officers found a second victim, a man in his 20s, who was also suffering from a gunshot wound. He was taken to Community Regional Medical Center.
Investigators say the two men were at a gathering when a disturbance occurred and shots were fired.
Several people left the area before police arrived. Now detectives are searching for anyone with information on what led up to the shooting.
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This is Fresno's 54th homicide of the year.