"Limit your distractions, put your phone away, slow down, get to your destinations safely. Your family, everyone's waiting for you to get there," said Officer Gregorio Rodriguez.
The California Highway Patrol shared photos on Friday showing one car wrapped around a streetlight and others caught in roadside debris.
They say the combination of wet weather and the holiday rush has caused a spike in crashes.
"Number one thing you can do is slow down," Officer Rodriguez said. "We don't want you hitting those puddles at 65-70 miles per hour."
The rain has left drivers with slick roads, mainly caused by clogged drains.
With the storm on a brief pause Friday morning, city workers in Fresno took advantage.
Action News was there as crews cleared a massive clog near Fink-White Park in southwest Fresno.
"It was a fairly simple fix, but when you're covering 112 square miles of city in Fresno, that's just a lot of area to cover," said Assistant Director of Public Works Brian Russell.
Russell said these short breaks between downpours are essential for keeping drains and other infrastructure running smoothly.
"We're using today to get caught up. We're going through and wrapping up some of the issues that we did have out there. We're checking all of our pumps making sure they're ready to go for the next storm, making sure our basins have plenty of capacity," Russell said, adding when the final bout of rain passes, the city's priority will turn to repairing roadways damaged by the storms.
"We will be blitzing those potholes, on these dry days that we have, to get as many of them filled as possible before the next series of storms come in," Russell said.
If you find yourself facing hazards on the road, Officer Rodriguez advises drivers to stay calm.
"Slow down, just let off the accelerator, ride it out, hold on to that steering wheel," Rodriguez said.
Anyone who encounters flooding or a dangerous pothole is encouraged to report it by calling 311 or using the FresGO app.