Naval Air Station Lemoore says the choice was difficult but necessary because of increased security measures and protection requirements.
The air show, which was scheduled to take place on March 21 and 22, was set to feature a demonstration from the Blue Angels.
RELATED: 2026 NAS Lemoore Air Show canceled amid Iran conflict
"Whenever you've got the U.S. military in the middle of an evolving fight, and a war is really what we should call it, you're going to have the Pentagon doing everything it can to conserve all the weaponry that we've got," ABC News Aviation Specialist John Nance said.
Nance says during the uncertainty, powerful war-fighting tools like the F-18's at Lemoore will be kept ready to go.
"I think what it comes down to is that the Pentagon is always going to take the conservative route, and if a war is breaking out and you don't know exactly how far it's going to go, you're going to cancel things like this, even though it is regrettable," Nance said.
The air show attracts thousands from out of town.
The City of Lemoore had planned to host a three-day Flight Fest during the show, which has also been canceled.
Although locals say they understand the decision, restaurants like Twisted Indian Street Food in Downtown and local vendors like Carrie Roe, will feel the economic impact.
"It's sad because they only come once every few years so it's going to be very sad for the community," Roe said.
The City of Lemoore says if and when the air show is rescheduled, they plan to host their flight fest to coincide with it.
For South Valley news updates, follow Kassandra Gutierrez on Facebook, Twitter and Instagram.