It happened just before 4 am Monday at Kings Canyon and Clovis.
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The California Highway Patrol is investigating the crash, but it appears two SUVs crashed into each other in the intersection and then hit a business. It is unoccupied and under renovation.
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It's not known exactly what led up to the crash.
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The road is now clear and open to traffic.
Stay with ABC30 for the latest details on this developing story.