Authorities have identified the man as 63-year-old Richard Neil.
The crash happened at E Central Ave and S Temperance Ave at about 7:45 am on Monday.
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The California Highway Patrol says the driver of one of the vehicles, a red car, ran a stop sign and crashed into a white pickup truck.
Officers say Neil died at the scene.
The driver of the pickup truck was rushed to the hospital. There is no word yet on his condition.
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CHP officers say alcohol or drugs do not seem to be a factor in the crash.
Investigation into the crash is ongoing.