The crash happened just before 7 pm on Highway 41 near Children's Boulevard.
The California Highway Patrol says a driver crashed into the back of a vehicle as traffic was stopped.
The vehicle that was hit was forced into the back of a second car, which was then pushed into a third.
Officers say the driver who was believed to be at fault was taken to the hospital, where they later died.
The cause of the crash is still under investigation, but drugs or alcohol are not suspected to be involved.
Stay with Action News for the latest updates on this developing story.