The Fresno Fire Department says the crash happened on Sierra Vista and Grant avenues just after 3 p.m. on Wednesday.
Firefighters say they had to help remove the man from the truck after it had hit three parked cars and crashed through the fence of a home.
He was taken to the hospital and his current condition has not been released.
Police say he suffered a medical emergency at the stop sign, which caused him to step on the accelerator.
He had his granddaughter with him in the truck but she was not injured.