Police say 17-year-old Merrick Asher and 15-year-old Mason Asher were in a Pontiac sedan with two other people when the car failed to yield at a stop sign at West Lincoln Avenue and Henderson Road, southwest of Fresno.
They crossed right in front of a Chevrolet pickup truck where a family of three was inside.
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Merric and Asher were both in the front of the car.
The other two passengers, plus a little boy in the truck, were taken to the hospital.
The crash is still under investigation.
The family of the victims have set up a GoFundMe account to help with funeral expenses here.