It happened around 2 am.
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The California Highway Patrol says Destiney Perez of Fresno was northbound on the highway when, for an unknown reason, she lost control of her truck.
The truck's front tire hit a concrete curb, and the vehicle hit a light pole before going up an embankment and overturning back down the hill.
The truck landed on its roof.
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Perez was pronounced dead at the scene.
Officials believe alcohol may have been a factor in the crash.