The California Highway Patrol says the 19-year-old driver was traveling on Highway 180 near Highway 63 at around 9 am when he went off the cliff.
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His vehicle went 300 feet down the mountain and crashed into a tree.
CHP officers say the driver was wearing a seatbelt and suffered moderate to major injuries. He was taken to Community Regional Medical Center in Fresno for treatment.
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Officials say the driver may have been speeding through the area. The cause of the crash is still under investigation.