The Fresno Police Department responded just after 1 a.m. to B Street near Cesar Chavez Boulevard for a multi-round shot spotter.
Police found the man unresponsive with a gunshot wound.
He was rushed to a nearby hospital, where he died.
No suspect information has been released but this is being investigated as a homicide.
If you have any information, you're asked to call the Fresno Police Department.