The pair burglarized the Cleveland Pharmacy and stole a large number of narcotics.
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Officers say the suspects broke the window above the security door at the front, then used a ladder to climb up and over.
Authorities believe the suspects knew what they wanted since they moved fast and didn't go through the entire store.
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Video also captured the getaway vehicle as it left the parking lot.
Anyone with information is asked to contact the Madera Police Department.