The California Highway Patrol received reports of the crash on Avenue 384 near Road 118 south of Dinuba at about 2:48 p.m.
Investigators say the 21-year-old was driving a black 2015 Ford Mustang east on Avenue 384 when he collided head-on with a white Ford pickup truck.
The CHP says the driver of the Mustang allowed his vehicle to cross over the double yellow lines into westbound traffic. The driver of the Mustang was not wearing a seatbelt and was ejected from the vehicle.
He was pronounced dead at the scene.
The driver of the pickup truck was a 62-year-old man and was transported to Kaweah Medical Center with major injuries.
The crash remains under investigation.
It is unknown if drugs or alcohol played a factor in the crash.
Anyone who witnessed the crash is asked to contact the California Highway Patrol.