It happened in the area of Palm and Robinson just before 3:30 am Monday.
Officers say the man was in a fight with his girlfriend when she stabbed him twice in the upper body.
Authorities say the woman's cousin also got involved and punched the man multiple times.
The suspects left the scene, and police are still searching for them.
The man was taken to the hospital and is expected to survive.
Anyone with more information is asked to contact the Fresno Police Department.
If you are the victim of domestic abuse, or you know someone who is, there is help available 24/7. In Fresno County, call the Marjaree Mason Center at (559) 233-4357. In all other locations, call the National Domestic Violence Hotline at (800) 799-7233.