It happened just after 8 pm Tuesday on Highway 99 and Manning Avenue in Fresno County.
The CHP says he was driving a pickup truck that was stopped in the middle of the freeway with no lights on.
The driver of a Dodge Ram crashed into the blacked-out truck.
The Dodge driver was not injured.
The driver of the pick-up was taken to the hospital with moderate to major injuries.
He's been identified as a 41-year-old man from Avenal.
Investigators say he was not wearing a seatbelt and has five prior DUIs.