The crash happened just after 3 pm near Elkhorn and Howard.
The California Highway Patrol says a man in a truck drove into the intersection after leaving a stop sign, ending up in the path of an oncoming big rig.
The semi-truck, which officials say did not have a stop sign, crashed into the man's truck, killing him.
A man in the passenger seat of the truck was taken to a local hospital with minor injuries.
The driver of the big rig was not injured.
Officials say drugs and alcohol were not involved in the accident.