It happened just before 4 pm Saturday on Highway 49 near Hilltop Lane.
The California Highway Patrol says a 27-year-old man was speeding when he made a sharp turn and ended up on the wrong side of the highway.
The motorcycle rider then crashed head-on into a motor home driven by a 26-year-old woman.
The man was pronounced dead at the scene.
Authorities say drugs and alcohol are not suspected in the crash.