The crash happened just before 6 pm in the are of Marks and Excelsior, which is right on the boundary line for Fresno and Kings counties.
Investigators say a pick-up truck stopped at a stop sign before driving into the path of a semi-truck.
The man driving the pick-up truck died at the scene.
A woman and three children, ages four to ten, were taken to the hospital.
Authorities expect all four passengers of the pick up truck to survive.
The driver of the semi-truck was unharmed.
PG&E is working to repair power poles damaged in the crash.