The Fresno Police Department responded to Floradora Avenue between Rowell and Barton just after 4:00 a.m.
Police say they received a three-round shot spotter alert.
The man was taken to the hospital, where he died from his injuries.
Police are searching for a suspect and motive for the shooting.
If you have any information, you can call the Fresno Police Department at (559) 621-7000.