Police say the driver of a white pickup truck was turning onto Gettysburg from Barton Avenue when the rider collided with the vehicle.
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The motorcyclist died at the scene. Their name has not been released.
Authorities said the motorcycle rider appeared to be driving at a high rate of speed before the crash, but an investigation was underway to determine who was at fault.
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A woman in her 50s who was inside the pickup truck was taken to the hospital for her injuries. Her condition was not immediately known.