The crash happened around 4 pm in the area of Fowler and Tulare avenues.
Fresno police say a 16-year-old boy riding a motorcycle and a vehicle were involved in the accident.
The teen was taken to a local hospital, where he later died.
Officials have not yet provided any other details about the crash.
The Clovis Unified School District tells Action News it believes the teenager was a student at Clovis East High School.
The district is making support available for students and staff on Thursday.