The California Highway Patrol says the collision happened on Road 6 at Highway 152 near Chowchilla.
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CHP officers say the driver of the Volvo sedan was heading south on Road 6.
She pulled into the traffic lanes of Highway 152, and into the path of a motorcycle that slammed into the left-hand door of the sedan.
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The man riding the motorcycle died at the scene. The driver of the sedan is okay.
One lane of traffic on both sides of Highway 152 at Road 6 have been shut down and will remain closed for at least the next two hours.